The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
Patient Handout
https://clinicaltrials.gov/study/NCT05538208
A research study to compare two ways to dose mycophenolate mofetil (MMF) to treat lupus nephritis either with:
Current approach: dosed by patient’s height and weight
New personalized approach: dosed by patient’s drug metabolism
Why?
To determine how safe and effective either MMF dosing type is in improving lupus nephritis in children and teens
Who?
Patients ages 8 to 20 years old with active lupus nephritis as per recent kidney biopsy will be randomly assigned to either MMF dosing type (current/height-weight or new/personalized)
When?
Eight study visits over the course of one year that can be done at the same time as your doctor’s appointments or infusions
What?
Routine blood and urine with first morning void samples
Blood samples to measure MMF levels in the blood
Surveys about your health and well-being
Where?
Contact: PLUMM@cchmc.org